3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide
CAS: 1009298-59-2
Molecular Formula: C19H17ClN2O3S
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide - Names and Identifiers
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide - Physico-chemical Properties
| Molecular Formula | C19H17ClN2O3S |
| Molar Mass | 388.87 |
| Density | 1.231 |
| Melting Point | 233-237oC |
| Water Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Solubility | DMSO 11 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| Appearance | Shape Solid Color Light Yellow |
| pKa | 14.45±0.46(Predicted) |
| Storage Condition | -20°C Freezer |
| Use | AZD2014 is a new mTOR inhibitor with IC50 of 2.8 nM. Highly selective action on various PI3K subtypes (α/β/γ/δ). |
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide - Risk and Safety
| HS Code | 29339900 |
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide - Introduction
AZD1981 is an effective, selective CRTh2 (DP2) receptor antagonist with an IC50 of 4 nM, which is more than 1000 times more selective than acting on 340 other enzymes and receptors (including DP1).
Last Update：2022-10-16 17:30:56
3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide - Biological activity
Vistusertib (AZD2014) is a new type of mTOR inhibitor, IC50 is 2.8 nM in cell-free test; It has high selectivity for various PI3K subtypes (α/β/& gamma;/& delta;). At a concentration of 1 μM, there is no or weak binding force for most kinases. AZD2014 can induce proliferation inhibition, apoptosis, cell cycle arrest and autophagy in HCC cells, and has anti-tumor activity.
Last Update：2024-04-09 20:48:19
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Spot supply
Product Name: 1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]- Visit Supplier Webpage Request for quotationCAS: 1009298-59-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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